PLGA nanoparticles loaded with KMP-11 stimulate innate immunity and induce the killing of Leishmania
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چکیده
منابع مشابه
PLGA Nanospheres Loaded with Autoclaved Leishmania Major (ALM) and CpG-ODN: Preparation and in vitro Characterization
Objective(s) Several antigens, adjuvants and delivery systems have been evaluated for induction of protective immune responses against Leishmaniasis, but most of them have been inefficient. In this study, PLGA nanospheres as antigen delivery system CpG-ODN as an immunoadjuvant for increasing the immune responses against Autoclaved Leishmania major (ALM) were prepared and characterized. Materi...
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Polymeric nanoparticles have received great attention as potential controlled drug delivery systems. Biodegradable polymers has been extensively used in the development of these drug carriers, and the polyesters such as polylactic acid, polyglycolic acid and their copolymers as poly-lactide-co-glycolide are the most used, considering its biocompatibility and biodegradability. Thermal analysis t...
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BACKGROUND Vaccine development has been a priority in the fight against leishmaniases, which are vector-borne diseases caused by Leishmania protozoa. Among the different immunization strategies employed to date is inoculation of plasmid DNA coding for parasite antigens, which has a demonstrated ability to induce humoral and cellular immune responses. In this sense, inoculation of plasmid DNA en...
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ژورنال
عنوان ژورنال: Nanomedicine: Nanotechnology, Biology and Medicine
سال: 2013
ISSN: 1549-9634
DOI: 10.1016/j.nano.2013.04.003